Yellow nail syndrome: a review
Identifieur interne : 000017 ( Main/Exploration ); précédent : 000016; suivant : 000018Yellow nail syndrome: a review
Auteurs : Stéphane Vignes [France] ; Robert Baran [France]Source :
- Orphanet Journal of Rare Diseases [ 1750-1172 ] ; 2017.
Abstract
Yellow nail syndrome (YNS; OMIM 153300, ORPHA662) is a very rare disorder that almost always occurs after 50 years of age but a juvenile or familial form has also been observed. YNS is diagnosed based on a triad associating yellow nail discoloration, pulmonary manifestations (chronic cough, bronchiectasia, pleural effusion) and lower limb lymphedema. Chronic sinusitis is frequently associated with the triad. YNS etiology remains unknown but a role of lymphatic impairment is usually evoked. YNS is more frequently isolated but may be associated in rare cases with autoimmune diseases, other clinical manifestations implicating lymphatic functions or cancer and, hence, is also considered a paraneoplastic syndrome. YNS management is symptomatic and not codified. YNS can resolve spontaneously. Oral vitamin E alone or even better when associated with triazole antifungals may achieve partial or total disappearance of nail discoloration. Pleural effusion can be treated surgically, with decortication/pleurectomy or pleurodesis. Antibiotic prophylaxis is prescribed for bronchiectasia with chronic sputum production. Lymphedema treatment is based on low-stretch bandages and the wearing of elastic compression garments combined with skin care, exercises and, as needed, manual lymph drainage.
Url:
DOI: 10.1186/s13023-017-0594-4
PubMed: 28241848
PubMed Central: 5327582
Affiliations:
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type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Baran, Robert" sort="Baran, Robert" uniqKey="Baran R" first="Robert" last="Baran">Robert Baran</name><affiliation wicri:level="3"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2188 3779</institution-id><institution-id institution-id-type="GRID">grid.7459.f</institution-id><institution></institution><institution>Nail Disease Centre,</institution></institution-wrap>42, rue des Serbes, 06400 Cannes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>42, rue des Serbes, 06400 Cannes</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Cannes</settlement></placeName></affiliation></author></analytic><series><title level="j">Orphanet Journal of Rare Diseases</title><idno type="eISSN">1750-1172</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Yellow nail syndrome (YNS; OMIM 153300, ORPHA662) is a very rare disorder that almost always occurs after 50 years of age but a juvenile or familial form has also been observed. YNS is diagnosed based on a triad associating yellow nail discoloration, pulmonary manifestations (chronic cough, bronchiectasia, pleural effusion) and lower limb lymphedema. Chronic sinusitis is frequently associated with the triad. YNS etiology remains unknown but a role of lymphatic impairment is usually evoked. YNS is more frequently isolated but may be associated in rare cases with autoimmune diseases, other clinical manifestations implicating lymphatic functions or cancer and, hence, is also considered a paraneoplastic syndrome. YNS management is symptomatic and not codified. YNS can resolve spontaneously. Oral vitamin E alone or even better when associated with triazole antifungals may achieve partial or total disappearance of nail discoloration. Pleural effusion can be treated surgically, with decortication/pleurectomy or pleurodesis. Antibiotic prophylaxis is prescribed for bronchiectasia with chronic sputum production. Lymphedema treatment is based on low-stretch bandages and the wearing of elastic compression garments combined with skin care, exercises and, as needed, manual lymph drainage.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Heller, J" uniqKey="Heller J">J Heller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samman, Pd" uniqKey="Samman P">PD Samman</name></author><author><name sortKey="White, Wf" uniqKey="White W">WF White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emerson, Pa" uniqKey="Emerson P">PA Emerson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hiller, E" uniqKey="Hiller E">E Hiller</name></author><author><name sortKey="Rosenow, Ec" uniqKey="Rosenow E">EC Rosenow</name></author><author><name sortKey="Olsen, Am" uniqKey="Olsen A">AM 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Austin</name></author><author><name sortKey="Smith, Km" uniqKey="Smith K">KM Smith</name></author><author><name sortKey="Wanchai, A" uniqKey="Wanchai A">A Wanchai</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Vignes, S" uniqKey="Vignes S">S Vignes</name></author><author><name sortKey="Arrault, M" uniqKey="Arrault M">M Arrault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decastro, A" uniqKey="Decastro A">A DeCastro</name></author><author><name sortKey="Mims, L" uniqKey="Mims L">L Mims</name></author><author><name sortKey="Hueston, Wj" uniqKey="Hueston W">WJ Hueston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudmik, L" uniqKey="Rudmik L">L Rudmik</name></author><author><name sortKey="Soler, Zm" uniqKey="Soler Z">ZM Soler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khalil, Hs" uniqKey="Khalil H">HS Khalil</name></author><author><name sortKey="Nunez, Da" uniqKey="Nunez D">DA Nunez</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li><li>Île-de-France</li></region><settlement><li>Cannes</li><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Vignes, Stephane" sort="Vignes, Stephane" uniqKey="Vignes S" first="Stéphane" last="Vignes">Stéphane Vignes</name></region><name sortKey="Baran, Robert" sort="Baran, Robert" uniqKey="Baran R" first="Robert" last="Baran">Robert Baran</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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